Atlas of Genetics and Cytogenetics in Oncology and Haematology DPP 4 ( dipeptidyl - peptidase 4 )
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چکیده
Note In 1979, a large molecular weight complex composed of adenosine deaminase (ADA) were reported to be found as an adenosine deaminase-binding protein (ADBP), also known as adenosine deaminase complexing protein-2 (ADCP2). In 1993, this adenosine deaminase-binding protein is determined to be identical to CD26, a T-cell activation molecule and a 110-kD glycoprotein that is present also on epithelial cells of various tissues including the liver, kidney, and intestine. The CD26 cDNA contains a 3465 bp open reading frame that encodes a 766 amino acid protein. The CD26 amino acid sequence has 85% amino acid identity with the mouse and rat CD26 genes and 37% amino acid identity with D. melanogaster. Two CD26 transcripts (4,2 and 2,8 kb) were found, both of which were expressed at high levels in the placenta and kidney and at moderate levels in the lung and liver. However, only the 4,2 kb mRNA was expressed at low levels in skeletal muscle, heart, brain, and pancreas.
منابع مشابه
SERPINB3 (serpin peptidase inhibitor, clade B (ovalbumin), member 3).
Review on SERPINB3, with data on DNA/RNA, on the protein encoded and where the gene is implicated.
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